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Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
journal contribution
posted on 2023-06-08, 11:15 authored by Tina M Thornton, Gustavo Pedraza-Alva, Bin Deng, David WoodDavid Wood, Alexander Aronshtam, James L Clements, Guadalupe Sabio, Roger J Davis, Dwight E Matthews, Bradley Doble, Mercedes RinconGlycogen synthase kinase 3beta (GSK3beta) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3beta activity is the primary mechanism that regulates this widely expressed active kinase. Although the protein kinase Akt inhibits GSK3beta by phosphorylation at the N terminus, preventing Akt-mediated phosphorylation does not affect the cell-survival pathway activated through the GSK3beta substrate beta-catenin. Here, we show that p38 mitogen-activated protein kinase (MAPK) also inactivates GSK3beta by direct phosphorylation at its C terminus, and this inactivation can lead to an accumulation of beta-catenin. p38 MAPK-mediated phosphorylation of GSK3beta occurs primarily in the brain and thymocytes. Activation of beta-catenin-mediated signaling through GSK3beta inhibition provides a potential mechanism for p38 MAPK-mediated survival in specific tissues.
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Publication status
- Published
Journal
ScienceISSN
0036-8075External DOI
Issue
5876Volume
320Page range
667-670Department affiliated with
- Biochemistry Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-04-17Usage metrics
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