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Y-family DNA polymerases and their role in tolerance of cellular DNA damage.

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journal contribution
posted on 2023-06-08, 11:03 authored by Julian E Sale, Alan LehmannAlan Lehmann, Roger Woodgate
The past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at the heart of this process, which is commonly known as translesion synthesis. This family of polymerases has unique features that enable them to synthesize DNA past damaged bases. However, as they exhibit low fidelity when copying undamaged DNA, it is essential that they are only called into play when they are absolutely required. Several layers of regulation ensure that this is achieved

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Nature Reviews Molecular Cell Biology

ISSN

1471-0072

Publisher

Nature Publishing Group

Volume

13

Page range

141-152

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-04-17

First Open Access (FOA) Date

2012-09-01

First Compliant Deposit (FCD) Date

2012-03-26

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