Y-family_DNA_polymerases.doc (668.5 kB)
Y-family DNA polymerases and their role in tolerance of cellular DNA damage.
journal contribution
posted on 2023-06-08, 11:03 authored by Julian E Sale, Alan LehmannAlan Lehmann, Roger WoodgateThe past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at the heart of this process, which is commonly known as translesion synthesis. This family of polymerases has unique features that enable them to synthesize DNA past damaged bases. However, as they exhibit low fidelity when copying undamaged DNA, it is essential that they are only called into play when they are absolutely required. Several layers of regulation ensure that this is achieved
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Publication status
- Published
File Version
- Accepted version
Journal
Nature Reviews Molecular Cell BiologyISSN
1471-0072Publisher
Nature Publishing GroupExternal DOI
Volume
13Page range
141-152Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-04-17First Open Access (FOA) Date
2012-09-01First Compliant Deposit (FCD) Date
2012-03-26Usage metrics
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