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Interferon Gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum

journal contribution
posted on 2023-06-08, 10:11 authored by R C Pollok, M J Farthing, M Bajaj-Elliot, I R Sanderson, V McDonald
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History

Publication status

  • Published

Journal

Gastroenterology

ISSN

0016-5085

Issue

1

Volume

120

Page range

99-107

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

This study demonstrates the role of IFNy in enterocyte resistance to C.parvum infection acting through JAK/STAT signalling and alteration of intracellular Fe. This may explain in part the variable susceptibility to infection in humans. Pollok was my PhD student. I was involved in all stages of the study.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-07

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