Ateh, D, Hussain, I, Mustafa, A, Price, K M, Nickols, C D, Bird, M M, Greensmith, L, Schiavo, G, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2006) Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease. Journal of Pathology, 208 (S1). 23A-23A. ISSN 0022-3417

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Abstract

Cytoplasmic dynein and its activating complex dynactin drive the retrograde transport of material necessary for the survival and proper functioning of neurons. Disruption of the dynein-dynactin complex by either over-expression of the dynamitin subunit or by mutations within individual dynein/dynactin subunits can cause motor neuron degeneration.

Item Type:	Article
Additional Information:	189th Meeting of the Pathological Society of Great Britain and Ireland. Robinson College, Cambridge. 4-6th January, 2006
Schools and Departments:	School of Life Sciences > Neuroscience
Depositing User:	EPrints Services
Date Deposited:	06 Feb 2012 21:13
Last Modified:	02 Jul 2012 14:18
URI:	http://sro.sussex.ac.uk/id/eprint/30309

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