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Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease
journal contribution
posted on 2023-06-08, 09:20 authored by D Ateh, I Hussain, A Mustafa, K M Price, C D Nickols, M M Bird, L Greensmith, G Schiavo, Majid HafezparastMajid Hafezparast, E M C Fisher, C S Baker, J E MartinCytoplasmic dynein and its activating complex dynactin drive the retrograde transport of material necessary for the survival and proper functioning of neurons. Disruption of the dynein-dynactin complex by either over-expression of the dynamitin subunit or by mutations within individual dynein/dynactin subunits can cause motor neuron degeneration.
History
Publication status
- Published
Journal
Journal of PathologyISSN
0022-3417Publisher
John Wiley and SonsExternal DOI
Issue
S1Volume
208Page range
23A-23ADepartment affiliated with
- Neuroscience Publications
Notes
189th Meeting of the Pathological Society of Great Britain and Ireland. Robinson College, Cambridge. 4-6th January, 2006Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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