McKendrick, Linda, Pain, Virginia M and Morley, Simon J (1999) Molecules in focus: translation initiation factor 4E. International Journal of Biochemistry and Cell Biology, 31 (1). pp. 31-35. ISSN 1357-2725

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Abstract

Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biochemistry
Depositing User:	Simon Morley
Date Deposited:	06 Feb 2012 21:13
Last Modified:	27 Apr 2012 09:06
URI:	http://sro.sussex.ac.uk/id/eprint/30283

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