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Molecules in focus: translation initiation factor 4E
journal contribution
posted on 2023-06-08, 09:19 authored by Linda McKendrick, Virginia M Pain, Simon MorleyTranslation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.
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Publication status
- Published
Journal
International Journal of Biochemistry and Cell BiologyISSN
1357-2725Publisher
ElsevierExternal DOI
Issue
1Volume
31Page range
31-35ISBN
1357-2725Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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