A dissection of volatility in yeast

Stoletzki, Nina, Welch, John, Hermisson, Joachim and Eyre-Walker, Adam (2005) A dissection of volatility in yeast. Journal of Molecular Evolution, 22 (10). pp. 2022-2026. ISSN 0022-2844

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It has been suggested that volatility, the proportion of mutations which change an amino acid, can be used to infer the level of natural selection acting upon a gene. This conjecture is supported by a correlation between volatility and the rate of nonsynonymous substitution (dN), or the ratio of nonsynonymous and synonymous substitution rates, in a variety of organisms. These organisms include yeast, in which the correlations are quite strong. Here we show that these correlations are a by-product of a correlation between synonymous codon bias toward translationally optimal codons and dN. Although this analysis suggests that volatility is not a good measure of the selection, we suggest that it might be possible to infer something about the level of natural selection, from a single genome sequence, using translational codon bias.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 21:10
Last Modified: 22 Mar 2012 14:33
URI: http://sro.sussex.ac.uk/id/eprint/29914
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