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Synonymous codon bias is not caused by mutation bias in G+C rich genes in humans
journal contribution
posted on 2023-06-08, 09:02 authored by N G Smith, Adam Eyre-WalkerAdam Eyre-WalkerIt is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the data were consistent with the action of natural selection or biased gene conversion. Similar patterns of polymorphism were also observed in noncoding DNA, suggesting that natural selection or biased gene conversion may affect large tracts of the human genome.
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Publication status
- Published
Journal
Molecular Biology and EvolutionISSN
0737-4038Issue
6Volume
18Page range
982-986Pages
5.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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