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The role of DSB repair-insights from human genetics.
journal contribution
posted on 2023-06-08, 08:35 authored by Mark O'DriscollMark O'Driscoll, Penny JeggoThe efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.
History
Publication status
- Published
Journal
Nature Reviews GeneticsISSN
1471-0056Publisher
Nature Publishing GroupExternal DOI
Issue
1Volume
7Page range
45-54Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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