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A complex 'mRNA degradation code' controls gene expression during animal development
Current understanding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradation rates are encoded within the mRNA message itself in the form of cis-regulatory elements bearing particular primary sequences and/or secondary-structures. Such control elements are operated by RNA-binding proteins (RBPs) and/or microRNA (miRNA)-containing complexes. Based on the large number of RBPs and miRNAs encoded in metazoan genomes, their complex developmental expression, and that specific RBP/miRNA interactions with mRNAs can lead to distinct degradation rates, I propose that developmental gene expression is shaped by a complex 'mRNA degradation code' with high information capacity. Localised cellular events involving the modification of RBP/miRNA target sequences in mRNAs by alternative polyadenylation and the activation of specific RBP/miRNA activities via cell signalling are predicted to further expand the capacity of the 'mRNA degradation code' by coupling it to dynamic events experienced by cells at specific spatio-temporal coordinates within the developing embryo
History
Publication status
- Published
Journal
Trends in GeneticsISSN
0168-9525Publisher
ElsevierExternal DOI
Issue
2Volume
28Page range
78-88Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-02-15Usage metrics
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