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Paradowski, Michael (2011) A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core. Tetrahedron Letters, 52 (44). pp. 5728-5732. ISSN 00404039
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2011.08.119
Abstract
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Michael Paradowski |
Date Deposited: | 06 Feb 2012 20:52 |
Last Modified: | 01 Jun 2012 08:38 |
URI: | http://sro.sussex.ac.uk/id/eprint/28525 |