Hughes, David C, Legan, P Kevin, Steel, Karen P and Richardson, Guy P (1998) Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness. Genomics, 48 (1). pp. 46-51. ISSN 08887543

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Abstract

a-Tectorin is one of the major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped the gene encoding a-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing a-tectorin have been identified, demonstrating physical linkage to the anonymous marker D11S925. This places a-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome. Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Neuroscience
Depositing User:	Kevin Legan
Date Deposited:	06 Feb 2012 20:52
Last Modified:	26 Mar 2012 12:57
URI:	http://sro.sussex.ac.uk/id/eprint/28516

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