Unexpected structure of Epstein–Barr virus lytic cycle activator Zta

Sinclair, Alison J. (2006) Unexpected structure of Epstein–Barr virus lytic cycle activator Zta. Trends in Microbiology, 14 (7). pp. 289-291. ISSN 0966-842X

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The key viral gene responsible for initiating the replicative cycle of EpsteinBarr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Alison Sinclair
Date Deposited: 06 Feb 2012 20:49
Last Modified: 06 Jun 2019 09:07
URI: http://sro.sussex.ac.uk/id/eprint/28329
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