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Unexpected structure of Epstein–Barr virus lytic cycle activator Zta
journal contribution
posted on 2023-06-08, 07:58 authored by Alison SinclairThe key viral gene responsible for initiating the replicative cycle of EpsteinBarr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.
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Publication status
- Published
Journal
Trends in MicrobiologyISSN
0966-842XPublisher
ElsevierExternal DOI
Issue
7Volume
14Page range
289-291Pages
3.0Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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