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Nitric Oxide Regulates Cell Proliferation during Drosophila Development

journal contribution
posted on 2023-06-08, 07:49 authored by Boris Kuzin, Ian Roberts, Nalalia Peunova, Grigori Enikolopov
Cell division and subsequent programmed cell death in imaginal discs of Drosophila larvae determine the final size of organs and structures of the adult fly. We show here that nitric oxide (NO) is involved in controlling the size of body structures during Drosophila development. We have found that NO synthase (NOS) is expressed at high levels in developing imaginal discs. Inhibition of NOS in larvae causes hypertrophy of organs and their segments in adult flies, whereas ectopic expression of NOS in larvae has the opposite effect. Blocking apoptosis in eye imaginal discs unmasks surplus cell proliferation and results in an increase in the number of ommatidia and component cells of individual ommatidia. These results argue that NO acts as an antiproliferative agent during Drosophila development, controlling the balance between cell proliferation and cell differentiation

History

Publication status

  • Published

Journal

Cell

ISSN

1474-9718

Publisher

Cell

Issue

4

Volume

87

Page range

639-649

ISBN

0092-8674

Department affiliated with

  • Biology and Environmental Science Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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