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From genetics to pathology: tau and a-synuclein assemblies in neurodegenerative diseases

journal contribution
posted on 2023-06-08, 07:46 authored by Michel Goedert, Maria Grazia Spillantini, Louise SerpellLouise Serpell, John Berriman, Michael J Smith, Ross Jakes, R Anthony Crowther
The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule¿associated protein tau or the protein a¿synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the a¿synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and a¿synuclein can cause neurodegeneration.

History

Publication status

  • Published

Journal

Philosophical Transactions B: Biological Sciences

ISSN

1471-2970

Publisher

Royal Society, The

Issue

1406

Volume

356

Page range

213-227

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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