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Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90
journal contribution
posted on 2023-06-08, 07:42 authored by Chrisostomos ProdromouChrisostomos ProdromouHsp90 is involved in the maturation and activation of client proteins. Often these are key proteins involved in signal transduction and regulatory pathways that in a mutated and/or deregulated form sustain an oncogenic cellular state. Consequently, the malignancy is maintained with the aid of Hsp90 upon which the mutated proteins have become particularly dependent for their activity. The requirement for the Hsp90 chaperone machine to drive the malignancy makes Hsp90 a prime anticancer target, an 'axle in a wheel' that when disrupted has been shown to be effective in killing cancerous cells. This review aims to identify potential drug targets, based on the current structural knowledge of the Hsp90-chaperone machine, that could be targeted with the aim of disrupting its functioning and promoting an anti-cancer activity.
History
Publication status
- Published
Journal
Current Topics in Medicinal ChemistryISSN
1568-0266Publisher
Bentham Science PublishersExternal DOI
Issue
15Volume
9Page range
1352-1368Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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