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Paradowski, Michael (2011) The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection. MedChemComm, 2 (3). pp. 185-189. ISSN 20402503
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Official URL: http://pubs.rsc.org/en/content/articlepdf/2011/md/...
Abstract
A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Michael Paradowski |
Date Deposited: | 06 Feb 2012 20:45 |
Last Modified: | 01 Jun 2012 08:22 |
URI: | http://sro.sussex.ac.uk/id/eprint/27935 |