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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

journal contribution
posted on 2023-06-08, 07:41 authored by Michael Paradowski
A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.

History

Publication status

  • Published

Journal

MedChemComm

ISSN

20402503

Publisher

Royal Society of Chemistry

Issue

3

Volume

2

Page range

185-189

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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