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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection
journal contribution
posted on 2023-06-08, 07:41 authored by Michael ParadowskiA series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.
History
Publication status
- Published
Journal
MedChemCommISSN
20402503Publisher
Royal Society of ChemistryIssue
3Volume
2Page range
185-189Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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