File(s) not publicly available
Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway
The NHEJ (non-homologous end-joining) pathway is one of the major mechanisms for repairing DSBs (double-strand breaks) that occur in genomic DNA. In common with eukaryotic organisms, many prokaryotes possess a conserved NHEJ apparatus that is essential for the repair of DSBs arising in the stationary phase of the cell cycle. Although the bacterial NHEJ complex is much more minimal than its eukaryotic counterpart, both pathways share a number of common mechanistic features. The relative simplicity of the prokaryotic NHEJ complex makes it a tractable model system for investigating the cellular and molecular mechanisms of DSB repair. The present review describes recent advances in our understanding of prokaryotic end-joining, focusing primarily on biochemical, structural and cellular aspects of the mycobacterial NHEJ repair pathway.
History
Publication status
- Published
ISSN
0067-8694Volume
76Page range
23-35Pages
13.0Presentation Type
- paper
Event name
Symposium on DNA Damage - From Causes to Cures, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, DEC 15-17, 2008Event type
conferenceISBN
978-1-85578-173-3Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC