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Interaction of cellular and network mechanisms for efficient pheromone coding in moths
journal contribution
posted on 2023-06-08, 07:24 authored by Hana Belmabrouk, Thomas NowotnyThomas Nowotny, Jean-Pierre Rospars, Dominique MartinezSensory systems, both in the living and in machines, have to be optimized with respect to their environmental conditions. The pheromone subsystem of the olfactory system of moths is a particularly well-defined example in which rapid variations of odor content in turbulent plumes require fast, concentration-invariant neural representations. It is not clear how cellular and network mechanisms in the moth antennal lobe contribute to coding efficiency. Using computational modeling, we show that intrinsic potassium currents (IA and ISK) in projection neurons may combine with extrinsic inhibition from local interneurons to implement a dual latency code for both pheromone identity and intensity. The mean latency reflects stimulus intensity, whereas latency differences carry concentration-invariant information about stimulus identity. In accordance with physiological results, the projection neurons exhibit a multiphasic response of inhibitionexcitationinhibition. Together with synaptic inhibition, intrinsic currents IA and ISK account for the first and second inhibitory phases and contribute to a rapid encoding of pheromone information. The first inhibition plays the role of a reset to limit variability in the time to first spike. The second inhibition prevents responses of excessive duration to allow tracking of intermittent stimuli.
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Publication status
- Published
Journal
Proceedings of the National Academy of Sciences of the United States of AmericaISSN
1091-6490Publisher
National Academy of SciencesExternal DOI
Issue
49Volume
108Page range
19790-19795Department affiliated with
- Informatics Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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