Mixture for controlling insecticide-resistant malaria vectors

Pennetier, Cédric, Costantini, Carlo, Corbel, Vincent, Licciardi, Séverine, Dabiré, Roch K, Lapied, Bruno, Chandre, Fabrice and Hougard, Jean-Marc (2008) Mixture for controlling insecticide-resistant malaria vectors. Emerging Infectious Diseases, 14 (11). pp. 1707-1714. ISSN 1080-6040

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The spread of resistance to pyrethroids in the major Afrotropical malaria vectors Anopheles gambiae s.s. necessitates the development of new strategies to control resistant mosquito populations. To test the efficacy of nets treated with repellent and insecticide against susceptible and insecticide-resistant An. gambiae mosquito populations, we impregnated mosquito bed nets with an insect repellent mixed with a low dose of organophosphorous insecticide and tested them in a rice-growing area near Bobo-Dioulasso, Burkina Faso. During the first 2 weeks posttreatment, the mixture was as effective as deltamethrin alone and was more effective at killing An. gambiae that carried knockdown resistance (kdr) or insensitive acetylcholinesterase resistance (Ace1R) genes. The mixture seemed to not kill more susceptible genotypes for the kdr or Ace1R alleles. Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified.

Item Type: Article
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 20:40
Last Modified: 26 Jul 2012 10:22
URI: http://sro.sussex.ac.uk/id/eprint/27318
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