Richardson, Guy P, Lukashkin, Andrei N and Russell, Ian J (2008) The tectorial membrane: one slice of a complex cochlear sandwich. Current Opinion in Otolaryngology & Head and Neck Surgery, 16 (5). pp. 458-464. ISSN 1068-9508

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Abstract

Purpose of review: The review is both timely and relevant, as recent findings have shown the tectorial membrane plays a more dynamic role in hearing than hitherto suspected, and that many forms of deafness can result from mutations in tectorial membrane proteins. Recent findings: Main themes covered are (i) the molecular composition, structural organisation and properties of the tectorial membrane, (ii) the role of the tectorial membrane as a second resonator and a structure within which there is significant longitudinal coupling, and (iii) how mutations in tectorial membrane proteins cause deafness in mice and men. Implications: Findings from experimental models imply that the tectorial membrane plays multiple, critical roles in hearing. These include coupling elements along the length of the cochlea, supporting a travelling wave and ensuring the gain and timing of cochlear feedback are optimal. The clinical findings suggest stable, moderate-to-severe forms hereditary hearing loss may be diagnostic of a mutation in TECTA, the gene encoding one of the major, non-collagenous proteins of the tectorial membrane.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biology and Environmental Science
Depositing User:	Guy Richardson
Date Deposited:	06 Feb 2012 20:39
Last Modified:	21 Mar 2012 16:23
URI:	http://sro.sussex.ac.uk/id/eprint/27302

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