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The tectorial membrane: one slice of a complex cochlear sandwich.

journal contribution
posted on 2023-06-08, 07:14 authored by Guy Richardson, Andrei N Lukashkin, Ian J Russell
Purpose of review: The review is both timely and relevant, as recent findings have shown the tectorial membrane plays a more dynamic role in hearing than hitherto suspected, and that many forms of deafness can result from mutations in tectorial membrane proteins. Recent findings: Main themes covered are (i) the molecular composition, structural organisation and properties of the tectorial membrane, (ii) the role of the tectorial membrane as a second resonator and a structure within which there is significant longitudinal coupling, and (iii) how mutations in tectorial membrane proteins cause deafness in mice and men. Implications: Findings from experimental models imply that the tectorial membrane plays multiple, critical roles in hearing. These include coupling elements along the length of the cochlea, supporting a travelling wave and ensuring the gain and timing of cochlear feedback are optimal. The clinical findings suggest stable, moderate-to-severe forms hereditary hearing loss may be diagnostic of a mutation in TECTA, the gene encoding one of the major, non-collagenous proteins of the tectorial membrane.

History

Publication status

  • Published

Journal

Current Opinion in Otolaryngology & Head and Neck Surgery

ISSN

1068-9508

Issue

5

Volume

16

Page range

458-464

Pages

7.0

Department affiliated with

  • Biology and Environmental Science Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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