File(s) not publicly available
Development of the hair bundle and mechanotransduction.
journal contribution
posted on 2023-06-08, 07:12 authored by Gowri D Nayak, Helen S K Ratnayaka, Richard GoodyearRichard Goodyear, Guy RichardsonThis review focuses on the cellular and molecular mechanisms underlying the development of the sensory hair bundle, an apical specialisation of the hair cell that is essential for mechanotransduction. The structure, function and development of the hair bundle is described, with an emphasis on the properties and possible roles played by the different link types that interconnect the individual elements of the hair bundle - the multiple stereocilia and the single kinocilium. Studies of mouse and zebrafish mutants have revealed that several classes of molecule are required for the genesis and maintenance of hair-bundle structure. These include cell surface molecules that are associated with the different hair-bundle links, along with myosin motors, scaffolding proteins and an actin cross-linker. Finally we consider how differences in the form and shape of hair bundles within and between different sensory organs are generated.
History
Publication status
- Published
Journal
International Journal of Developmental BiologyISSN
0214- 6282External DOI
Issue
6-7Volume
51Page range
597-608Pages
9.0Department affiliated with
- Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC