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The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor
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posted on 2023-06-08, 07:11 authored by Dimitris Kallifidas, Ben Pascoe, Gillian A Owen, Claire M Strain-Damerell, Hee-Jeon Hong, Mark PagetMark PagetStreptomyces coelicolor mutants lacking the zinc-responsive Zur repressor are conditionally defective in sporulation, presumably due to the overexpression of one or more Zur target genes. Gene disruption analyses revealed that deregulation of previously known Zur targets was not responsible for the sporulation phenotype. We used microarrays to identify further Zur targets and discovered that Zur controls a cluster of genes predicted to direct synthesis of an uncharacterized siderophore-related non-ribosomally encoded peptide designated coelibactin. Disruption of a key coelibactin biosynthetic gene suppressed the Zur sporulation phenotype, suggesting that deregulation of coelibactin synthesis inhibits sporulation.
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Publication status
- Published
Journal
Journal of BacteriologyISSN
0021-9193External DOI
Issue
2Volume
192Page range
608-611Pages
4.0Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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