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The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor

journal contribution
posted on 2023-06-08, 07:11 authored by Dimitris Kallifidas, Ben Pascoe, Gillian A Owen, Claire M Strain-Damerell, Hee-Jeon Hong, Mark PagetMark Paget
Streptomyces coelicolor mutants lacking the zinc-responsive Zur repressor are conditionally defective in sporulation, presumably due to the overexpression of one or more Zur target genes. Gene disruption analyses revealed that deregulation of previously known Zur targets was not responsible for the sporulation phenotype. We used microarrays to identify further Zur targets and discovered that Zur controls a cluster of genes predicted to direct synthesis of an uncharacterized siderophore-related non-ribosomally encoded peptide designated coelibactin. Disruption of a key coelibactin biosynthetic gene suppressed the Zur sporulation phenotype, suggesting that deregulation of coelibactin synthesis inhibits sporulation.

History

Publication status

  • Published

Journal

Journal of Bacteriology

ISSN

0021-9193

Issue

2

Volume

192

Page range

608-611

Pages

4.0

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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