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Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch

journal contribution
posted on 2023-06-08, 07:10 authored by Sarah Bishop, T Kline, A Martinez Arias, Juan Pablo Couso
The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent cells through Notch signalling. These cells form a patterning boundary from which a putative secondary signal leads to the development of leg joints. Elsewhere in the tarsal segments, signalling by DELTA and NOTCH is necessary far the development of non-joint parts of the leg. We propose that these two effects result from different thresholds of NOTCH activation, which are translated into different downstream gene expression effects. We propose a general mechanism for creation of boundaries by Notch signalling.

History

Publication status

  • Published

Journal

Development

ISSN

0950-1991

Publisher

Development

Issue

13

Volume

126

Page range

2993-3003

ISBN

0950-1991

Department affiliated with

  • Biochemistry Publications

Notes

Describes a role for Notch signalling in insect leg segmentation which might be akin to mesoderm and neural segmentation in vertebrates

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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