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Model studies towards the total synthesis of the anticancer agent roseophilin
journal contribution
posted on 2023-06-08, 07:05 authored by Eddy Viseux, P J Parsons, J B J Pavey, C M Carter, I PintoIn our new approach to the anticancer agent roseophilin (1), a concise, stereocontrolled synthesis of the bicyclic model system 16 was achieved. Key steps include a diastereoselective Ireland-Claisen rearrangement and a stereoselective construction of the hexahydro-cyclopenta[b]pyrrol-6-one core via a tandem intramolecular aza-Wittig/[3+2]-cycloaddition sequence
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Publication status
- Published
Journal
SYNLETTISSN
0936-5214Publisher
ThiemeExternal DOI
Issue
12Volume
2003Page range
1856-1858Pages
3.0Department affiliated with
- Chemistry Publications
Notes
EMEV did virtually all the synthetic work and co wrote the paper. This paper features an original tandem aza-Wittig / 1,3-dipolar cycloaddition to assemble bicyclic cores with full control over four chiral centers. This is currently applied to a route towards the total synthesis of the anticancer agent roseophilin.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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