Lehmann, Alan R (2003) Replication of Damaged DNA. Cell Cycle, 2 (4). pp. 299-301. ISSN 1538-4101
Full text not available from this repository.Abstract
DNA damage is generated continually inside cells. In order to be able to replicate past damaged bases (translesion synthesis), the cell employs a series of specialised DNA polymerases, which singly or in combination, are able to bypass many different types of damage. The polymerases have similar structural domains to classical polymerases, but they have a more open structure to allow altered bases to fit into their active sites. Although not required for replication of undamaged DNA, some at least of these polymerases are located in replication factories. Emerging evidence suggests that the polymerase switch from replicative to translesion polymerases might be mediated by post-translational modifications
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Sussex Centre for Genome Damage and Stability |
Related URLs: | |
Depositing User: | Alan Lehmann |
Date Deposited: | 06 Feb 2012 20:37 |
Last Modified: | 07 Jun 2021 13:38 |
URI: | http://sro.sussex.ac.uk/id/eprint/27012 |