Tools
Tools
Stultz, Brian G, Ray, Robert P and Hursh, Deborah A (2005) Analysis of the shortvein cis-regulatory region of the decapentaplegic gene of Drosophila melanogaster. Genesis, 42 (3). pp. 181-192. ISSN 1526-954X
Full text not available from this repository.Abstract
In mammals, the Transforming Growth Factor-ß (TGF-ß) superfamily controls a variety of developmental processes. In Drosophila, by contrast, a single member of the superfamily, decapentaplegic (dpp) performs most TGF-ß developmental functions. The complexity of dpp functions is reflected in the complex cis-regulatory sequences that flank the gene. Dpp is divided into three regions: Hin, including the protein-coding exons; disk, including 3' cis-regulatory sequences; and shortvein (shv), including noncoding exons and 5' cis-regulatory sequences. We analyzed the cis-regulatory structure of the shortvein region using a nested series of rearrangement breakpoints and rescue constructs. We delimit the molecular regions responsible for three mutant phenotypes: larval lethality, wing venation defects, and head capsule defects. Multiple overlapping elements are responsible for larval lethality and wing venation defects. However, the area regulating head capsule formation is distinct, and resides 5' to these elements. We have demonstrated this by isolating and describing two novel dpp alleles, which affect only the adult head capsule. genesis 42:181¿192, 2005. © 2005 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Additional Information: | Collaboration with Dr. Hursh, article describes a genetic and molecular dissection of the 5'-cis-regulatory sequences of the BMP decapentaplegic, and identifies a new element of controlling head capsule morphogenesis. Dr. Ray's contribution included the molecular characterization of Tegula, the shortvein inter se, and the SEM study on head capsule defects. |
| Schools and Departments: | School of Life Sciences > Evolution, Behaviour and Environment |
| Depositing User: | Robert Ray |
| Date Deposited: | 06 Feb 2012 20:37 |
| Last Modified: | 22 Mar 2012 10:41 |
| URI: | http://sro.sussex.ac.uk/id/eprint/27002 |