Leg patterning driven by Proximal-Distal interactions and EGFR signaling

Galindo, M I, Bishop, S A, Greig, S and Couso, J P (2002) Leg patterning driven by Proximal-Distal interactions and EGFR signaling. Science, 297. pp. 256-259. ISSN 0036-8075

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wingless and decapentaplegic signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development. However, here we show that wingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates

Item Type: Article
Additional Information: All authors members of my lab including S. Greig. I managed the project, designed and executed experiments and wrote the paper. Here we amended the existing paradigm for proximal-distal appendage development in arthropods, revealing a wingless and dpp-independent patterning driven by EGFR. Reviewed in Nature and quoted over 50 times.
Schools and Departments: School of Life Sciences > Biochemistry
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User: Maximo Ibo Galindo-Orozco
Date Deposited: 06 Feb 2012 20:32
Last Modified: 21 Sep 2017 10:32
URI: http://sro.sussex.ac.uk/id/eprint/26493
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