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Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

journal contribution
posted on 2023-06-08, 06:40 authored by Corne Kros, W Marcotti, S M van Netten, T J Self, R T Libby, S D M Brown, Guy Richardson, K P Steel
Mutations in Myo7a cause hereditary deafness in mice and humans. We describe the effects of two mutations, Myo7a6J and Myo7a4626SB, on mechano-electrical transduction in cochlear hair cells. Both mutations result in two major functional abnormalities that would interfere with sound transduction. The hair bundles need to be displaced beyond their physiological operating range for mechanotransducer channels to open. Transducer currents also adapt more strongly than normal to excitatory stimuli. We conclude that myosin VIIA participates in anchoring and holding membrane-bound elements to the actin core of the stereocilium. Myosin VIIA is therefore required for the normal gating of transducer channels.

History

Publication status

  • Published

Journal

Nature Neuroscience

ISSN

1097-6256

Issue

1

Volume

5

Page range

41-47

Pages

7.0

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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