A new folding paradigm for repeat proteins

Kajander, Tommi, Cortajarena, Aitziber L, Main, Ewan R G, Mochrie, Simon G J and Regan, L (2005) A new folding paradigm for repeat proteins. Journal of the American Chemical Society, 127 (29). pp. 10188-10190. ISSN 0002-7863

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The folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.

Item Type: Article
Additional Information: ERGM was one of three joint first authors, who designed, carried out the research, analyzed data and wrote the paper. A new paradigm for non-cooperative protein equilibrium unfolding and thus the first example of predicting the unfolding behaviour in repeat proteins. The research has been presented at many international conferences.
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Ewan Main
Date Deposited: 06 Feb 2012 20:30
Last Modified: 30 Nov 2012 17:07
URI: http://sro.sussex.ac.uk/id/eprint/26190
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