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A new folding paradigm for repeat proteins
journal contribution
posted on 2023-06-08, 06:28 authored by Tommi Kajander, Aitziber L Cortajarena, Ewan R G Main, Simon G J Mochrie, L ReganThe folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.
History
Publication status
- Published
Journal
Journal of the American Chemical SocietyISSN
0002-7863Publisher
American Chemical SocietyPublisher URL
External DOI
Issue
29Volume
127Page range
10188-10190Pages
3.0Department affiliated with
- Chemistry Publications
Notes
ERGM was one of three joint first authors, who designed, carried out the research, analyzed data and wrote the paper. A new paradigm for non-cooperative protein equilibrium unfolding and thus the first example of predicting the unfolding behaviour in repeat proteins. The research has been presented at many international conferences.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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