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A new folding paradigm for repeat proteins

journal contribution
posted on 2023-06-08, 06:28 authored by Tommi Kajander, Aitziber L Cortajarena, Ewan R G Main, Simon G J Mochrie, L Regan
The folding/unfolding transitions of a series of designed consensus tetratricopeptide repeat proteins are quantitatively described by the classical one-dimensional Ising model, which thus represents a new folding paradigm for repeat proteins. Moreover, for the first time for any protein, a theoretical model predicts the folding/unfolding transition midpoint and the width of the transition.

History

Publication status

  • Published

Journal

Journal of the American Chemical Society

ISSN

0002-7863

Publisher

American Chemical Society

Issue

29

Volume

127

Page range

10188-10190

Pages

3.0

Department affiliated with

  • Chemistry Publications

Notes

ERGM was one of three joint first authors, who designed, carried out the research, analyzed data and wrote the paper. A new paradigm for non-cooperative protein equilibrium unfolding and thus the first example of predicting the unfolding behaviour in repeat proteins. The research has been presented at many international conferences.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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