Mellado Lagarde, Marcia M, Drexl, Markus, Lukashkina, Victoria A, Lukashkin, Andrei N and Russell, Ian J (2008) Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Nature Neuroscience, 11. pp. 746-748. ISSN 1097-6256

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Abstract

Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaDeltaENT/DeltaENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaDeltaENT/DeltaENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biology and Environmental Science
Depositing User:	Marcia Maria Mellado Lagarde
Date Deposited:	06 Feb 2012 20:27
Last Modified:	30 Nov 2012 17:06
URI:	http://sro.sussex.ac.uk/id/eprint/26006

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