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Does the cochlea compromise on sensitivity and frequency selectivity?

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posted on 2023-06-08, 06:01 authored by Lukashkin, Lukashkina, Guy Richardson, Russell
A tenet of cochlear physiology is that sharp tuning and sensitivity are directly interrelated. Here we show a reciprocal interdependence between tuning and sensitivity in the mammalian cochlea from measurements of basilar membrane (BM) mechanical tuning and neural Suppression tuning curves of wild-type (Tectb(+/+)) and beta-tectorin mutant (Tectb(-/-)) mice. The tectorial membrane (TM) of the mutants lacks striated-sheet matrix, which is likely to decrease longitudinal elastic coupling. Mechanical and neural tuning curves recorded in mutants are slightly less sensitive, although more sharply tuned. The inverse relationship between sensitivity and tuning observed in the mutants Could be attributed to smaller numbers of the outer hair cells responding in synchrony due to reduced longitudinal coupling in the TM. We suggest that frequency tuning and high sensitivity are not necessarily concomitant but reciprocal properties of the cochlea.

History

Publication status

  • Published

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD

Pages

7.0

Presentation Type

  • paper

Event name

10th International Workshop on the Mechanics of Hearing Keele Univ, Staffordshire, ENGLAND, JUL 27-31, 2008

Event location

Keele Univ, Staffordshire, ENGLAND

Event type

conference

ISBN

978-981-283-377-8

Department affiliated with

  • Biology and Environmental Science Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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