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Reply to Macaulay et al. (1999): mtDNA recombination - reasons to panic
journal contribution
posted on 2023-06-08, 05:59 authored by Adam Eyre-WalkerAdam Eyre-Walker, Noel H Smith, John Maynard SmithWe recently presented evidence of recombination in human mitochondrial DNA (mtDNA) using a data set of largely complete human mtDNAs gleaned from GenBank and the literature. It was pointed out that some of the sequences are probably incorrect and that, when those sequences are removed, so too is the evidence of recombination. Nevertheless, we argue that there is still evidence of recombination. First, there are excessive numbers of homoplasies in other mtDNA data sets. Second, an expanded data set of our own, excluding the sequences which are the subject of suspicion, shows a significant excess of homoplasies and, hence, evidence of recombination.
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Publication status
- Published
Journal
Proceedings B: Biological SciencesISSN
0962-8452Publisher
Royal Society, TheExternal DOI
Issue
1433Volume
266Page range
2041-2042Pages
2.0Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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