Medford, N. and Critchley, H.D. (2010) Conjoint activity of anterior insular and anterior cingulate cortex:awareness and response. Brain Structure and Function, 214 (5-6). pp. 535-549. ISSN 1863-2653

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Abstract

There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a close functional relationship, such that they may be considered together as input and output regions of a functional system. This system is typically engaged across cognitive, affective, and behavioural contexts, suggesting that it is of fundamental importance for mental life. Here, we review the literature and reinforce the case that these brain regions are crucial, firstly, for the production of subjective feelings and, secondly, for co-ordinating appropriate responses to internal and external events. This model seeks to integrate higher-order cortical functions with sensory representation and autonomic control: it is argued that feeling states emerge from the raw data of sensory (including interoceptive) inputs and are integrated through representations in conscious awareness. Correspondingly, autonomic nervous system reactivity is particularly important amongst the responses that accompany conscious experiences. Potential clinical implications are also discussed. © 2010 The Author(s).

Item Type:	Article
Keywords:	anterior insular cortices
Schools and Departments:	Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User:	Hazelle Woodhurst
Date Deposited:	28 Oct 2010
Last Modified:	26 Sep 2017 11:02
URI:	http://sro.sussex.ac.uk/id/eprint/2512

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