Ward, Simon (2008) Antagonists of the human adenosine A(2A) receptor. Part 1: Discovery and synthesis of thieno[3,2-d] pyrimidine-4-methanone derivatives. Bioorganic and Medicinal Chemistry Letters, 18 (9). pp. 2916-2919. ISSN 0960894X
Full text not available from this repository.Abstract
The (-)-(11R,2'S)-enantiomer of the antimalarial drug mefloquine has been found to be a reasonably potent and moderately selective adenosine A(2A) receptor antagonist. Further investigation of this compound has led to the discovery of a series of keto-aryl thieno[3,2-d]pyrimidine derivatives, which are potent and selective antagonists of the adenosine A(2A) receptor. These derivatives show selectivity against the A(1) receptor. Furthermore, some of these compounds have been shown to have in vivo activity in a commonly used model, suggesting the potential for the treatment of Parkinson's disease
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Simon Ward |
Date Deposited: | 06 Feb 2012 20:11 |
Last Modified: | 26 Jan 2018 13:01 |
URI: | http://sro.sussex.ac.uk/id/eprint/24549 |