Adaptive protein evolution in Drosophila

Smith, Nick G C and Eyre-Walker, Adam (2002) Adaptive protein evolution in Drosophila. Nature, 415. pp. 1022-1024. ISSN 0028-0836

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For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level1, 2. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level3, 4, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.

Item Type: Article
Additional Information: One of the first estimates of the rate of adaptive substitution. Cited by several textbooks. AEW designed the analysis, devised the method, did some of the analysis and wrote the paper. NS, who was a post-doc with AEW at the time, collected the data and did some of the analysis.
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 20:10
Last Modified: 21 Mar 2012 13:48
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