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Gap junctions in Drosophila: developmental expression of the whole innexin family
journal contribution
posted on 2023-06-08, 04:58 authored by Lucy A Stebbings, Martin G Todman, Rose Phillips, Claire E Greer, Jennifer Tam, Pauline Phelan, Kirsten Jacobs, Jonathan Bacon, Jane DaviesInvertebrate gap junctions are composed of proteins called innexins and eight innexin encoding loci have been identified in the now complete genome sequence of Drosophila melanogaster. The intercellular channels formed by these proteins are multimeric and previous studies have shown that, in a heterologous expression system, homo- and hetero-oligomeric channels can form, each combination possessing different gating characteristics. Here we demonstrate that the innexins exhibit complex overlapping expression patterns during oogenesis, embryogenesis, imaginal wing disc development and central nervous system development and show that only certain combinations of innexin oligomerization are possible in vivo. This work forms an essential basis for future studies of innexin interactions in Drosophila and outlines the potential extent of gap-junction involvement in development.
History
Publication status
- Published
Journal
Mechanisms of DevelopmentISSN
0925-4773External DOI
Issue
2Volume
113Page range
197-205Department affiliated with
- Biology and Environmental Science Publications
Notes
This paper surveys gap junction gene expresssion in Drosophila. It provides a basis for future work and allows deductions to be made about interactions between these genes in different tissues. All the authors except Bacon and Davies were employed on grants on which Davies was PI.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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