Gap junctions in Drosophila: developmental expression of the whole innexin family

Stebbings, Lucy A, Todman, Martin G, Phillips, Rose, Greer, Claire E, Tam, Jennifer, Phelan, Pauline, Jacobs, Kirsten, Bacon, Jonathan P and Davies, Jane (2002) Gap junctions in Drosophila: developmental expression of the whole innexin family. Mechanisms of Development, 113 (2). pp. 197-205. ISSN 0925-4773

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Invertebrate gap junctions are composed of proteins called innexins and eight innexin encoding loci have been identified in the now complete genome sequence of Drosophila melanogaster. The intercellular channels formed by these proteins are multimeric and previous studies have shown that, in a heterologous expression system, homo- and hetero-oligomeric channels can form, each combination possessing different gating characteristics. Here we demonstrate that the innexins exhibit complex overlapping expression patterns during oogenesis, embryogenesis, imaginal wing disc development and central nervous system development and show that only certain combinations of innexin oligomerization are possible in vivo. This work forms an essential basis for future studies of innexin interactions in Drosophila and outlines the potential extent of gap-junction involvement in development.

Item Type: Article
Additional Information: This paper surveys gap junction gene expresssion in Drosophila. It provides a basis for future work and allows deductions to be made about interactions between these genes in different tissues. All the authors except Bacon and Davies were employed on grants on which Davies was PI.
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 20:06
Last Modified: 21 Mar 2012 11:36
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