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Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on the behavioural satiety sequence

journal contribution
posted on 2023-06-08, 00:59 authored by K. G. T. Pulman, E. M. Somerville, Pete CliftonPete Clifton
Intra-accumbens stimulation of GABA receptors results in a robust increase in food intake. However the differential consequences of stimulating GABA(A) and GABA(B) receptors in the nucleus accumbens have not been extensively explored with respect to feeding behaviour. Here we compare the effects of the GABA(B) receptor agonist baclofen and GABA(A) receptor agonist muscimol, infused into the nucleus accumbens shell, on food intake and related behavior patterns. Baclofen (110–440 ?mol) dose dependently enhanced intake and delayed the onset of satiety within the test period as did the effects of 4–8 h food withdrawal. Muscimol (220–660 ?mol) enhanced intake but also disrupted the sequence of associated behaviours at every dose tested. We conclude that GABA(B) receptors in the nucleus accumbens shell may play a role in relation to feeding motivation whereas GABA(A) receptors may, as previously suggested, have a more restricted role in relation to the motor components of approach to food and ingestion.

History

Publication status

  • Published

Journal

Pharmacology Biochemistry and Behavior

ISSN

0091-3057

Publisher

Elsevier

Issue

1

Volume

97

Page range

156-162

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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