Pemberton, Trevor J, Rulten, Stuart L and Kay, John E (2003) Identification and characterisation of Schizosaccharomyces pombe cyclophilin 3 and its human homologue cyclophilin 20. Journal of Chromatography B, 786 (1-2). pp. 81-91. ISSN 1570-0232

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Abstract

We have identified nine cyclophilins encoded in the genome of the fission yeast Schizosaccharomyces pombe (Sp). Cyclophilin 3 is an orthologue of hUSA-CyP, which is associated with Prp4/Prp3 in the [U4/U6·U5] snRNP complex and Prp18, both of which are components of the pre-mRNA splicing machinery. PPIase assays have shown SpCyp3 and hUSA-CyP to have comparable activity and substrate specificity, but SpCyp3 has a reduced sensitivity to CsA correlating with a difference in the catalytic site. Prp3, Prp4 and Prp18 proteins exist in S. pombe and nuclear localisation of SpCyp3 has been shown, indicating conservation of function between hUSA-CyP and SpCyp3.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User:	Stuart Rulten
Date Deposited:	06 Feb 2012 19:59
Last Modified:	07 Jun 2019 09:44
URI:	http://sro.sussex.ac.uk/id/eprint/23456

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