Signaling Pathways Open the GAITway to Translational Control

Morley, Simon J and Willett, Mark (2008) Signaling Pathways Open the GAITway to Translational Control. Developmental Cell, 15 (5). pp. 639-640. ISSN 1534-5807

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In activated monocytes, Interferon modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Simon Morley
Date Deposited: 06 Feb 2012 19:58
Last Modified: 21 Mar 2012 14:20
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