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Signaling Pathways Open the GAITway to Translational Control

journal contribution
posted on 2023-06-08, 00:47 authored by Simon Morley, Mark Willett
In activated monocytes, Interferon modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a recent issue of Molecular Cell, show that the kinases themselves are regulated by the same translational silencing they promote thereby providing a negative feedback loop to limit late inflammatory gene expression.

History

Publication status

  • Published

Journal

Developmental Cell

ISSN

1534-5807

Issue

5

Volume

15

Page range

639-640

Pages

2.0

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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