The COP9/signalosome complex is conserved in fission yeast and has a role in S phase

Mundt, Kirsten E, Porte, Joanne, Murray, Johanne M, Brikos, Constantinos, Christensen, Per U, Caspari, Thomas, Hagan, Iain M, Millar, Jonathan B A, Simanis, Viesturs, Hofmann, Kay and Carr, Anthony M (1999) The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Current Biology, 9 (23). pp. 1427-1430.

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The COP9/signalosome complex is conserved from plant to mammalian cells. In Arabidopsis, it regulates the nuclear abundance of COP1, a transcriptional repressor of photomorphogenic development [1] [2]. All COP (constitutive photomorphogenesis) mutants inappropriately express genes that are normally repressed in the dark. Eight subunits (Sgn1-Sgn8) of the homologous mammalian complex have been purified [3] [4]. Several of these have been previously identified through genetic or protein interaction screens. No coherent model for COP9/signalosome function has yet emerged, but a relationship with cell-cycle progression by transcriptional regulation, protein localisation or protein stability is possible. Interestingly, the COP9/signalosome subunits possess domain homology to subunits of the proteasome regulatory lid complex [5] [6]. Database searches indicate that only Sgn5/JAB1 is present in Saccharomyces cerevisiae, precluding genetic analysis of the complex in cell-cycle regulation. Here we identify a subunit of the signalosome in the fission yeast Schizosaccharomyces pombe through an analysis of the DNA-integrity checkpoint. We provide evidence for the conservation of the COP9/signalosome complex in fission yeast and demonstrate that it functions during S-phase progression.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Johanne Murray
Date Deposited: 06 Feb 2012 19:56
Last Modified: 30 Nov 2012 17:05
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