Mouse models for ATR deficiency

O'Driscoll, Mark (2009) Mouse models for ATR deficiency. DNA Repair, 8 (11). pp. 1333-1337. ISSN 1568-7864

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ATM and ATR orchestrate overlapping DNA damage responses in reply to different forms of DNA strand discontinuities. But, knockout mouse models suggest that ATR is essential for viability in contrast to ATM. Recently, more sophisticated mouse models have been published including a conditional ATR-knockdown system and by modelling the human ATR-Seckel syndrome-causative mutation. Here, I will overview and contrast these models highlighting the advances both represent in our understanding of how defects in the ATR-dependent DNA damage response can impact on normal development, tissue homeostasis, ageing and cancer. © 2009 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: GDSC314
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Gee Wheatley
Date Deposited: 08 Apr 2010
Last Modified: 03 Jul 2019 00:47
Google Scholar:6 Citations

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