Smc5/6: a link between DNA repair and unidirectional replication?

Murray, Johanne M and Carr, Antony M (2008) Smc5/6: a link between DNA repair and unidirectional replication? Nature Reviews Molecular Cell Biology, 9. pp. 177-182. ISSN 1471-0072

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Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication. The literature suggests that Smc5/6 coordinates DNA repair, in part through post-translational modification of uncharacterized target proteins that can dictate their subcellular localization, and that Smc5/6 also functions to establish DNA-damage-dependent cohesion. A nucleolar-specific Smc5/6 function has been proposed because Smc5/6 yeast mutants display penetrant phenotypes of ribosomal DNA (rDNA) instability. rDNA repeats are replicated unidirectionally. Here, we propose that unidirectional replication, combined with global Smc5/6 functions, can explain the apparent rDNA specificity.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Gee Wheatley
Date Deposited: 09 Apr 2010
Last Modified: 02 Oct 2019 10:16
Google Scholar:34 Citations

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