Eyre-Walker, A and Smith, N G (2001) Why are translationally sub-optimal synonymous codons used in Escherichia coli? Journal of Molecular Evolution, 53 (3). pp. 225-236. ISSN 0022-2844
Full text not available from this repository.Abstract
Natural selection favors certain synonymous codons which aid translation in Escherichia coli, yet codons not favored by translational selection persist. We use the frequency distributions of synonymous polymorphisms to test three hypotheses for the existence of translationally sub-optimal codons: (1) selection is a relatively weak force, so there is a balance between mutation, selection, and drift; (2) at some sites there is no selection on codon usage, so some synonymous sites are unaffected by translational selection; and (3) translationally sub-optimal codons are favored by alternative selection pressures at certain synonymous sites. We find that when all the data is considered, model 1 is supported and both models 2 and 3 are rejected as sole explanations for the existence of translationally sub-optimal codons. However, we find evidence in favor of both models 2 and 3 when the data is partitioned between groups of amino acids and between regions of the genes. Thus, all three mechanisms appear to contribute to the existence of translationally sub-optimal codons in E. coli.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Evolution, Behaviour and Environment |
Depositing User: | Adam Eyre-Walker |
Date Deposited: | 06 Feb 2012 19:51 |
Last Modified: | 21 Mar 2012 10:03 |
URI: | http://sro.sussex.ac.uk/id/eprint/22563 |