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Life can be stressful without ATR
A new study reports the first mouse model for ATR-mutated Seckel syndrome. The mice show phenotypes recapitulating the human disorder and provide insights into how reduced ATR function affects normal embryonic development by increasing replicative stress, ultimately resulting in an accelerated aging phenotype postnatally.
History
Publication status
- Published
File Version
- Published version
Journal
Nature GeneticsISSN
1061-4036Publisher
Nature Publishing GroupExternal DOI
Issue
8Volume
41Page range
866-868Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
GDSC291Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2009-09-21First Compliant Deposit (FCD) Date
2018-03-19Usage metrics
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