Adams, Benjamin, Beresford, Kenneth J M, Whyte, Sheena M and Young, Douglas W (2000) Stereochemistry of the reaction of the inhibitor β-chloroalanine with mercaptoethanol, a β-substitution reaction catalysed by an aminotransferase. Chemical Communications, 7. 619 - 620.
Full text not available from this repository.Abstract
L-Aspartate aminotransferase, a member of the α-family of PLP mediated enzymes, which normally catalyses transamination, has been used to catalyse the β-substitution reaction of stereospecifically labelled samples of the enzyme inhibitor β-chloro-L-alanine with 2-mercaptoethanol; the stereochemistry of the products was assigned by independent synthesis, showing that the abnormal substitution reaction proceeds with overall retention of stereochemistry, the usual stereochemical consequence of reactions catalysed by enzymes of the β-family of PLP mediated enzymes which have low homology with enzymes of the α-family
Item Type: | Article |
---|---|
Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | EPrints Services |
Date Deposited: | 06 Feb 2012 19:43 |
Last Modified: | 29 Mar 2012 06:16 |
URI: | http://sro.sussex.ac.uk/id/eprint/21857 |