Radioresistant glioma stem cells-Therapeutic obstacle or promising target?

Chalmers, Anthony J (2007) Radioresistant glioma stem cells-Therapeutic obstacle or promising target? DNA Repair, 6 (9). pp. 1391-1394. ISSN 1568-7864

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Attempts to improve outcomes for patients with glioblastoma multiforme have focused largely on dose intensification and multimodal therapy and have been met with limited success. An alternative approach involves identifying and targeting the mechanisms responsible for tumour resistance. Recent data suggests that these high grade malignancies harbour a population of glioma stem cells that are both radioresistant and capable of initiating tumour regrowth. Furthermore, the radioresistant phenotype may be the consequence of constitutively upregulated and hyper-responsive cell cycle checkpoint pathways. This article considers whether these findings herald the dawn of a new era of effective, targeted therapy for this refractory tumour.

Item Type: Article
Additional Information: Endnotes Ref: GDSC267
Keywords: DNA repair/DNA Damage/genetics/Humans/Neoplastic stem cells
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Gee Wheatley
Date Deposited: 23 Mar 2009
Last Modified: 02 Jul 2019 16:16

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